Severe or life-threatening haemorrhage, . during anticoagulant therapy: The coumarin anticoagulant should be withdrawn and an intravenous injection of Konakion MM given slowly in a dose of 5-10 mg together with fresh frozen plasma (FFP) or prothrombin complex concentrate (PCC). The dose of vitamin K 1 can be repeated as needed. The prothrombin level should be estimated three hours later and, if the response has been inadequate, the dose should be repeated. Not more than 40mg of Konakion MM should be given intravenously in 24 hours.