Use: Quality Muscle Gain, Cutting
Dosage: Beginners: 200-300 mg/week Hobby: 300-600 mg/week Pro: 400-1000 mg/week Women: 100-200 mg/week
Period: 12 - 24 weeks
Primobolan Depot (methonolone enanthate) is the injectable version of the steroid methenolone. This is the same constituent in primobolan orals (methenolone acetate), although here an enanthate ester is used to slow the steroid's release from the site of injection. Methenolone enanthate offers a similar pattern of steroid release as testosterone enanthate, with blood hormone levels remaining markedly elevated for approximately 2 weeks. Methenolone itself is a moderately strong anabolic steroid with very low androgenic properties. Its anabolic effect is considered to be slightly less than Deca-Durabolin (nandrolone decanoate) on a milligram for milligram basis. Methenolone enanthate is most commonly used during cutting cycles, when lean mass gain, not a raw mass increase, is the main objective.
The prescribing guidelines for Primobolan Depot recommend a maximum dosage of 200 mg at the onset of therapy, and a continuing dosage of 100 mg every week. Prolonged administration protocols generally call for a 100 mg dosage every 1-2 weeks, or 200 mg every 2-3 weeks. The usual administration protocols among male athletes call for a 200-400 mg per week dosage, which is taken for 12 to 24 weeks, which is sufficient to promote very noticeable increases in lean muscle tissue. It is, however, not unusual to see the drug taken in doses as high as 600 mg per week or more, although such amounts are likely to highlight a more androgenic side of methenolone, as well as exacerbate its negative effects on serum lipids.
Methenolone enanthate is often stacked with other (typically stronger) steroids in order to obtain a faster and more enhanced effect. During a dieting or cutting phase, a non-aromatizing androgen like Halotestin or trenbolone can be added. The stronger androgenic component here should help to bring about an added density and hardness to the muscles. On the other hand, one might add another mild anabolic steroid such as stanozolol. The result of such a combination should again be a notable increase in muscle mass and hardness, which still should not be accompanied by greatly increased side effects. Methenolone enanthate is also used effectively during bulking phases of training. In such a scenario, the addition of testosterone or boldenone would prove quite effective for adding new muscle mass without presenting any notable hepatotoxicity to the user.
Interactions with other drugs inhibitors of microsomal oxidation increase the concentration of amlodipine in plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes – reduce. Antihypertensive effect of weakening non-steroidal anti-inflammatory drugs, especially indomethacin (sodium retention and synthesis of prostaglandins kidney blockade), Alpha adrenostimulyatorov , estrogens (sodium retention), sympathomimetic. Thiazide and “loop” diuretics, alpha, beta-blockers, veropamil, angiotensin-converting enzyme inhibitors and nitrates increase antianginal and antihypertensive effects. Amiodarone, quinidine, alpha 1-blockers, antipsychotic drugs (neuroleptics) and blockers “slow” calcium channels may increase the hypotensive effect. It has no impact on the pharmacokinetic parameters of digoxin and warfarin. Cimetidine did not affect the pharmacokinetics of amlodipine. When used together with lithium preparations primobolan results before and after , may increase manifestations of neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus). calcium can reduce the effect of blockers “slow” calcium channels. procainamide, quinidine and other drugs causing prolongation of the interval , reinforce the negative inotropic effect and may increase the risk of significant lengthening interval. Pharmacokinetics of amlodipine does not change with concomitant administration with cimetidine. grapefruit juice may reduce amlodipine plasma concentration, but this decrease is so small that it does not significantly alter the effect of amlodipine.