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Chronic administration of theacrine (for seven days) did not appear to cause any significant sensitization to the locomotor enhancing properties of theacrine, as the increase in locomotion seen on day one (294%) was similar to day seven (259% enhancement) which exceeded control groups at both time points.  In contrast, administration of caffeine via infusion over seven days tends to induce sensitization;  the reason for this difference between theacrine and caffeine is not yet known as long-term tests have not yet been conducted.
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